Response to Nondepolarizing Muscle Relaxants in Children with Tumours

New developments in nondepolarizing muscle relaxants.

Anesthesiologists perceive that the ideal muscle relaxant is not yet available, particularly the nondepolarizing one with a rapid onset and a short duration of action. There is also a need for relaxants with different durations of action but which would be free from side effects. During the process of this development several new compounds have been tested and four have reached an advanced stat...

Pretreatment with sedative-hypnotics, but not with nondepolarizing muscle relaxants, attenuates alfentanil-induced muscle rigidity.

STUDY OBJECTIVE To evaluate and compare the efficacy of various pretreatment agents to attenuate or prevent opioid-induced muscle rigidity using a well-established, previously described clinical protocol. DESIGN Prospective, controlled, single-blind, partially randomized study. SETTING Large medical center. PATIENTS ASA physical status I-III patients undergoing elective surgical procedure...

Denervation supersensitivity: the response to depolarizing muscle relaxants.

The chemical theory of neuromuscular transmission (Dale, Feldberg and Vogt, 1936) is now almost universally accepted, and implicates acetylcholine as the neuromuscular transmitter. Depolarizing muscle relaxants act, at least initially, in a manner similar to acetylcholine and are believed to produce their effects by prolonged depolarization, but in certain situations these agents, instead of pr...

The Use of Muscle Relaxants in Infants and Children.

The belief that the use of muscle relaxants in infants and children is both unnecessary and dangerous has not been substantiated by subsequent clinical experience. The important advances that have been made recently in paediatric anaesthesia are due largely to the introduction of muscle relaxants, which have reduced the need for toxic agents to a minimum and have emphasized the importance of co...

Use of muscle relaxants.